Lymphoepithelioma-like carcinoma

Lymphoepithelioma-like carcinoma
Classification and external resources

Low magnification micrograph of a lymphoepithelioma-like carcinoma showing the characteristic squamoid nests in association with clusters of lymphocytes. H&E stain.

Lymphoepithelioma-like carcinoma, abbreviated LELC, is a malignant epithelial derived tumour, i.e. a type of carcinoma, and similar to lymphoepithelioma (nasopharyngeal carcinoma).

It can be considered a subtype of squamous cell carcinoma; however, some advocate it be considered a separate entity.[1]

In most anatomical sites, many cases are associated with the Epstein-Barr virus.[2]

In the breast, the macroscopic, microscopic, epidemiologic, and prognostic features of LELC are very similar to medullary carcinoma; EBV status is one differentiator.[3]

See also

References

  1. ^ Skinner, NE.; Horowitz, RI.; Majmudar, B. (Oct 2000). "Lymphoepithelioma-like carcinoma of the uterine cervix.". South Med J 93 (10): 1024–7. PMID 11147469. 
  2. ^ Mayer, EK.; Beckley, I.; Winkler, MH. (Mar 2007). "Lymphoepithelioma-like carcinoma of the urinary bladder--diagnostic and clinical implications.". Nat Clin Pract Urol 4 (3): 167–71. doi:10.1038/ncpuro0725. PMID 17347662. 
  3. ^ Lespagnard, L.; Cochaux, P.; Larsimont, D.; Degeyter, M.; Velu, T.; Heimann, R. (Apr 1995). "Absence of Epstein-Barr virus in medullary carcinoma of the breast as demonstrated by immunophenotyping, in situ hybridization and polymerase chain reaction.". Am J Clin Pathol 103 (4): 449–52. PMID 7726142.